Friday, March 25, 2022
The amygdala — a brain structure enlarged in two-year-old children diagnosed with autism spectrum disorder (ASD) — begins its accelerated growth between 6 and 12 months of age, suggests a study funded by the National Institutes of Health. The amygdala is involved in processing emotions, such as interpreting facial expressions or feeling afraid when exposed to a threat. The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth.
The study included 408 infants, 270 of whom were at higher likelihood of ASD because they had an older sibling with ASD, 109 typically developing infants, and 29 infants with Fragile X syndrome, an inherited form of developmental and intellectual disability. The researchers conducted MRI scans of the children at 6, 12 and 24 months of age. They found that the 58 infants who went on to develop ASD had a normal-sized amygdala at 6 months, but an enlarged amygdala at 12 months and 24 months. Moreover, the faster the rate of amygdala overgrowth, the greater the severity of ASD symptoms at 24 months. The infants with Fragile X syndrome had a distinct pattern of brain growth. They had no differences in amygdala growth but enlargement of another brain structure, the caudate, which was linked to increased repetitive behaviors.
The research team, part of the NIH Autism Centers of Excellence Infant Brain Imaging Study network, was led by Mark Shen, Ph.D., of the University of North Carolina at Chapel Hill and the Infant Brain Imaging Study. The study appears in the American Journal of Psychiatry. Funding was provided by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences and National Institute of Mental Health.
The authors suggest that difficulty processing sensory information during infancy may stress the amygdala, leading to its overgrowth.
ASD is a complex developmental disorder that affects how a person behaves, interacts with others, communicates and learns.
Alice Kau, Ph.D., of the NICHD Intellectual and Developmental Disabilities Branch, is available for comment.
Shen, MD. Subcortical brain development in autism and fragile X syndrome: evidence for dynamic, age-and disorder-specific trajectories in infancy. American Journal of Psychiatry. 2022. DOI:
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